Inclusion Criteria:
- Patients must be able to provide written informed consent form (ICF)
- Must be willing and able to complete baseline and follow-up HRQoL instruments, for
which patients must be proficient in either English or Spanish
- AML patients must be at least 55 years of age at the time of informed consent.
- MF, ICUS, and MDS patients must be at least 18 years of age at the time of informed
consent.
Newly diagnosed Idiopathic Cytopenias of Undetermined Significance (ICUS), Myelodysplastic
Syndromes (MDS), Acute Myeloid Leukemia (AML) patients:
- Newly diagnosed primary or secondary disease. To be considered "newly diagnosed", a
patient's confirmed diagnosis must be made no more than 60 days prior to the date of
consent signature. (An additional 5-day window [i.e., up to 65 days prior to the date
of ICF signature] may be allowed in special circumstance upon sponsor approval)
- Cohort assignment confirmed by central eligibility review. Cohort assignment must also
be confirmed by the site.
Myelofibrosis (MF) patients:
- Patients who initiated their first active systemic treatment for MF and/or MF-related
cytopenias within 90 days prior to the date of consent signature. This cohort allows
the enrollment of subjects with a diagnosis of Myelodysplastic/Myeloproliferative
overlap syndromes (MDS/MPN overlap syndrome).
- Cohort assignment is confirmed by the site. Central eligibility review is not
required.
Treated Lower-Risk Myelodysplastic Syndromes (LR-MDS) patients:
- Patients who have initiated first active treatment regimen containing at least one
non-ESA therapy, within 90 days prior to ICF
- Cohort assignment is confirmed by site. Central eligibility review is not required.
Exclusion Criteria:
- Suspected or proven acute promyelocytic leukemia (APL) (FAB M3 or WHO 2008) based on
morphology, immunophenotype, molecular assay or karyotype
- Currently enrolled in any interventional clinical trial where the patient is being
treated with an investigational product that cannot be identified.
- Idiopathic Cytopenias of Undetermined Significance (ICUS), Myelodysplastic Syndromes
(MDS) patients who received or are receiving active (disease modifying) therapy for
the treatment of MDS prior to the date of informed consent.
- Acute Myeloid Leukemia (AML) patients who initiated active (disease modifying
treatment for AML more than 2 weeks prior to the date of consent.
- Myelofibrosis (MF) and Myelodysplastic/Myeloproliferative (MDS/MPN) overlap syndrome
patients with suspected juvenile myelomonocytic leukemia (JMML).
Recruiting
