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Trial ID CA076-001  |   NCT05678283

A Study of Absorption, Metabolism, and Elimination CC-90010 in Participants With Advanced Solid Tumors

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Summary

  • Phase 1
  • Male Gender icon
  • 18+
    Age Range
  • 1
    Locations
  • BMS Not Yet Recruiting Study icon
    Not Yet Recruiting

Overview

The purpose of this study is to assess the absorption, metabolism, and elimination of CC-90010 and its metabolites following a single oral dose of radiolabeled CC-90010 in participants with advanced solid tumors.

Key Eligibility Criteria

Inclusion Criteria: - Males ≥ 18 years of age - Has histological or cytological confirmation of advanced solid tumors including those who have progressed on standard anticancer therapy or for whom no other approved conventional therapy exists - Eastern Cooperative Oncology Group Performance Status (ECOG PS) of 0 to 1 Exclusion Criteria: - Persistent diarrhea National Cancer Institute Common Terminology Criteria for Adverse Events (NCI CTCAE) Grade ≥ 2 - History of concurrent second cancers requiring active and ongoing systemic treatment Other protocol-defined inclusion/exclusion criteria apply

Treatment Options

Study Arms

ASSIGNED INTERVENTION

Study Arms

Experimental: Part 1: CC-90010 followed by [14C]CC-90010

ASSIGNED INTERVENTION
  • Drug: [14C]CC-90010, CC-90010

Study Arms

Experimental: Part 2: CC-90010

ASSIGNED INTERVENTION
  • Drug: CC-90010
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