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Recruiting
Phase 1/2 Study of MRTX849 in Patients With Cancer Having a KRAS G12C Mutation KRYSTAL-1
This study will evaluate the safety, tolerability, drug levels, molecular effects, and clinical activity of MRTX849 (adagrasib) in patients with advanced solid tumors that have a KRAS G12C mutation.
Experimental: Phase 1 Dose Exploration
Experimental: Phase 1b Expansion
Experimental: Phase 2
Experimental: Phase 2 Combination with Cetuximab
Experimental: Pilot Phase 1b Combination with Afatinib
Experimental: Pilot Phase 1b Combination with Cetuximab
Experimental: Pilot Phase 1b Combination with Cetuximab in NSCLC
Experimental: Pilot Phase 1b Combination with Cetuximab in PDAC
Experimental: Pilot Phase 1b Combination with Pembrolizumab