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Trial ID CV029-1024  |   NCT07226817

A Study to Assess the Relative Bioavailability of BMS-986435 and Food Effect on the BMS-986435 in Healthy Adult Participants

Summary

  • Phase 1
  • Male and Female Gender icon
  • 18-60
    Age Range
  • 1
    Locations
  • BMS Recruiting Study icon
    Recruiting

Overview

This study is designed to evaluate the relative bioavailability (rBA) of multiple test tablet formulations of BMS-986435 compared to an equal dose of the BMS-986435 reference tablet formulation. The effect of food on the selected BMS-986435 tablet formulation will also be evaluated.

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Key Eligibility Criteria

Inclusion Criteria - Participants must have a body weight of ≥ 45 kg and BMI between 18 and 32 kg/m2, inclusive - Participants must be healthy as determined by medical history, physical examination, vital signs, 12-lead electrocardiogram (ECG), clinical laboratory assessments - Participants must have documented left ventricular ejection fraction (LVEF) ≥ 60% and absence of significant cardiac abnormality at screening, as determined by local transthoracic echocardiogram (TTE) assessment - Other protocol-defined Inclusion/Exclusion criteria apply

Treatment Options

Study Arms

ASSIGNED INTERVENTION

Study Arms

Experimental: Treatment A

ASSIGNED INTERVENTION
  • Drug: BMS-986435

Study Arms

Experimental: Treatment B

ASSIGNED INTERVENTION
  • Drug: BMS-986435

Study Arms

Experimental: Treatment C

ASSIGNED INTERVENTION
  • Drug: BMS-986435

Study Arms

Experimental: Treatment D

ASSIGNED INTERVENTION
  • Drug: BMS-986435

Study Arms

Experimental: Treatment E

ASSIGNED INTERVENTION
  • Drug: BMS-986435

Study Arms

Experimental: Treatment F

ASSIGNED INTERVENTION
  • Drug: BMS-986435

Study Arms

Experimental: Treatment G

ASSIGNED INTERVENTION
  • Drug: BMS-986435
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