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Ícono de BMS, studio Reclutando

Recruiting

ID del estudio CA244-0010  |   NCT07100080

Study of Izalontamab Brengitecan (BMS-986507) Versus Platinum-Pemetrexed for EGFR-mutated Non-small Cell Lung Cancer After Failure of EGFR TKI Therapy (IZABRIGHT-Lung01)

Resumen

  • Phase 2/Phase 3
  • Ícono de género masculino y femenino
  • 18+
  • 92
  • Ícono de BMS, studio Reclutando
    Recruiting

Descripción general

A Study of Izalontamab Brengitecan (BMS-986507) versus Platinum-Pemetrexed for EGFR-mutated Non-small Cell Lung Cancer after failure of EGFR TKI Therapy

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Centro de reclutamiento más cercano

Criterios clave de elegibilidad

Inclusion Criteria: - Non-squamous NSCLC, not amenable to treatment in curative intent. - Documented evidence of EGFR mutation (exon 19 deletion, L858R mutation). - Progressive disease on a 3rd-generation (such as osimertinib, furmonertinib, lazertinib,...) EGFR-TKI-based mono- or combination therapy regimen as the most recent line of therapy in an adjuvant, locally advanced, or metastatic treatment setting. - Eligible to receive a platinum-based doublet chemotherapy regimen (either cisplatin or carboplatin in combination with pemetrexed). Exclusion criteria: - Inadequate organ function and/or bone marrow reserve. - Leptomeningeal metastases or spinal cord compression. - Poorly controlled systemic medical conditions. - Other protocol-defined inclusion/exclusion criteria apply.

Opciones de tratamiento

Brazos del estudio

INTERVENCIÓN ASIGNADA

Brazos del estudio

Experimental: Arm A

INTERVENCIÓN ASIGNADA
  • Drug: Iza-bren

Brazos del estudio

Experimental: Arm B

INTERVENCIÓN ASIGNADA
  • Drug: Iza-bren

Brazos del estudio

Active Comparator: Arm C

INTERVENCIÓN ASIGNADA
  • Drug: Carboplatin, Cisplatin, Pemetrexed

Brazos del estudio

Experimental: Arm D

INTERVENCIÓN ASIGNADA
  • Drug: Iza-bren

Brazos del estudio

Active Comparator: Arm E

INTERVENCIÓN ASIGNADA
  • Drug: Carboplatin, Cisplatin, Pemetrexed
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