Share Icon Health Study Area: Cardiovascular Disease Chevron Icon Health Study Area: Genitourinary For Patients Health Study Area: Lung Cancer Page Icon Phone Icon For Caregivers Health Study Area: AutoImmune Disease Health Study Area: Melanoma Location Icon Print YouTube Icon For Parents Health Study Area: Lung Cancer Print Created with Sketch. Help Icon Green Check Icon Search Icon Instagram Created with sketchtool. Direction Arrow Icon Error Icon For Parents Health Study Area: Blood Cancer Help Icon Health Study Area: NASH Gender Both Bookmark Icon Health Study Area: Melanoma Created with Sketch. Glossary Print Health Study Area: Blood Cancer Health Study Area: Genitourinary Health Study Area: Gastrointestinal Cancer Mobile Menu Icon Created with Sketch. Health Study Area: Cardiovascular Disease Health Study Area: Women's Cancer Communities Map Icon Created with Sketch. For Caregivers Health Study Area: Fibrosis Health Study Area: AutoImmune Disease FAQs Health Study Area: Head and Neck Cancer Created with Sketch. For Clinicians Chevron Right Icon Gender Female Health Study Area: Breast Cancer Direction Arrow Icon Gender Both Right Arrow Icon LinkedIn Icon Green Check Icon Gender Male Health Study Area: Fibrosis For Patients Twitter Icon Email Icon Facebook Icon Health Study Area: Gastrointestinal Cancer Health Study Area: Head and Neck Cancer For Clinicians External Link Icon

Menú

Buscar estudios clínicos de BMS
Ícono de BMS, studio Reclutando

Recruiting

ID del estudio CA127-1088  |   NCT07223671

Study to Evaluate the Effect of Repotrectinib on the Drug Levels of Transporter and CYP P450 Probe Substrates in Healthy Adult Participants

Resumen

  • Phase 1
  • Ícono de género masculino y femenino
  • 18-60
  • 1
  • Ícono de BMS, studio Reclutando
    Recruiting

Descripción general

The purpose of the study if to evaluate the effect of Repotrectinib on the drug levels of transporter and CYP P450 probe substrates in healthy adult participants.

Imprimir Imprimir
Email Correo electrónico

Centro de reclutamiento más cercano

Criterios clave de elegibilidad

Criterios de inclusión

Criterios de inclusión Icon
  • Participants must have a body mass index (BMI) of 18.0 to 32.0 kg/m2 and should be between the ages of 18-60 years inclusive.
    1. Healthy female (as assigned at birth) participants who are individuals not of childbearing potential (INOCBP) and healthy males with no clinically significant deviation from normal for the following: medical history, physical examination, vital signs, 12-lead ECG, and clinical laboratory assessment results as determined by the investigator.

      Criterios de exclusión

      Criterios de exclusión Icon
      • Participants must not have a significant history of clinical manifestation of any metabolic, allergic, dermatological, renal, hematological, pulmonary, cardiovascular, gastrointestinal, neurological, respiratory, endocrine, psychiatric, neoplastic, or genitourinary abnormalities/diseases as determined by the investigator or designee.
        Información Adicional *
        • Other protocol-defined Inclusion/Exclusion criteria apply.

          Opciones de tratamiento

          Brazos del estudio

          INTERVENCIÓN ASIGNADA

          Brazos del estudio

          Experimental: Cohort 1

          INTERVENCIÓN ASIGNADA
          • Drug: Repotrectinib, Metformin, Digoxin, Rosuvastatin

          Brazos del estudio

          Experimental: Cohort 2

          INTERVENCIÓN ASIGNADA
          • Drug: Repotrectinib, Bupropion, Flurbiprofen, Omeprazole
          Dé el primer paso para ver si es compatible con un estudio clínico - Verifique su elegibilidad
          Verifique su elegibilidad
          Responda algunas preguntas sobre su salud para ver si puede ser compatible con este enstudio.
          Compatibilizar con un estudio
          Si es compatible, haga clic en el estudio para ver la lista de ubicaciones de los centros del estudio.
          Seleccione una ubicación del centro del estudio
          Seleccione una ubicación del centro del estudio que sea conveniente para usted
          Registrarse
          Proporcione sus datos de contacto para que el centro del estudio se comunique con usted.

          Ayúdenos a mejorar su experiencia en el sitio web. Comparta sus comentarios con nuestro equipo en BMS Clinical Trials para mejorar su experiencia y la de los demás. Gracias