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CAR T cell and multiple myeloma cell

Investigational arlocabtagene autoleucel (arlo-cel) research in relapsed/refractory multiple myeloma (RRMM)1

A phase 3 trial comparing arlo-cel to standard of care is open for enrollment1

Find Out More See arlo-cel MOA

Explore Investigational arlo-cel Clinical Trials​

Arlo-cel phase 2 study2

Arlo-cel phase 3 study1,3

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Find a QUINTESSENTIAL-2 clinical trial location​

CAR=chimeric antigen receptor; DPd=daratumumab + pomalidomide + dexamethasone; Kd=carfilzomib + dexamethasone; MOA=mechanism of action.

References: 1. A study to compare the efficacy and safety of BMS-986393 versus standard regimens in adult participants with relapsed or refractory and lenalidomide-exposed multiple myeloma (QUINTESSENTIAL-2). ClinicalTrials.gov identifier: NCT06615479. Updated February 10, 2026. Accessed February 13, 2026. https://clinicaltrials.gov/study/NCT06615479 2. Study of arlocabtagene autoleucel (BMS-986393) a GPRC5D-directed CAR T cell therapy in adult participants with relapsed or refractory multiple myeloma (QUINTESSENTIAL). ClinicalTrials.gov identifier: NCT06297226. Updated February 10, 2026. Accessed February 13, 2026. https://clinicaltrials.gov/study/NCT06297226 3. Popat R, Larson SM, Varshavsky-Yanovsky A, et al. QUINTESSENTIAL-2: a phase 3 study comparing efficacy and safety of arlocabtagene autoleucel (arlo-cel) versus standard regimens in adult patients with relapsed or refractory multiple myeloma (RRMM) refractory to lenalidomide. J Clin Oncol. 2025;43(16)(suppl):TPS7564. doi:10.1200/JCO.2025.43.16_suppl.TPS7564