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Ícono de BMS, studio Reclutando

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ID del estudio CA240-0008  |   NCT06672523

A Study to Evaluate the Mass Balance, Metabolism, Elimination, and Drug Levels of [14C]-BMS-986504 (MRTX1719) in Participants With Advanced Solid Tumors With Homozygous Methylthioadenosine Phosphorylase Deletion

Resumen

  • Phase 1
  • Ícono de género masculino y femenino
  • 18+
  • 2
  • Ícono de BMS, studio Reclutando
    Recruiting

Descripción general

The purpose of this study is to evaluate the mass balance, metabolism, elimination, and drug levels of [14C]-BMS-986504 (MRTX1719) in participants with advanced solid tumors with homozygous methylthioadenosine phosphorylase deletion.

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Criterios clave de elegibilidad

Criterios de inclusión

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  • Participants must have an advanced, unresectable, or metastatic solid tumor malignancy with a deletion of the methylthioadenosine phosphorylase (MTAP) gene.
    1. Participants must have received, be refractory to, be ineligible for, or be intolerant of available standard care for their cancer.

      Criterios de exclusión

      Criterios de exclusión Icon
      • Participants must not have a history of any surgical or medical conditions possibly affecting how the study drug is distributed, broken down (metabolized) and removed (excreted or eliminated) from the body.
        1. Participants must not have participated in a clinical study involving a radiolabeled study drug within 12 months prior to admission to the research center.
          1. Participants must not have a current or recent (within 3 months of study drug administration) gastrointestinal disease.
            Información Adicional *
            • Other protocol-defined Inclusion/Exclusion criteria apply.

              Opciones de tratamiento

              Brazos del estudio

              INTERVENCIÓN ASIGNADA

              Brazos del estudio

              Experimental: [14C]-BMS-986504 followed by BMS-986504 Monotherapy

              INTERVENCIÓN ASIGNADA
              • Drug: BMS-986504, [14C]-BMS-986504
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