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Trial ID CC-99282-NHL-001  |   NCT03930953

A Safety and Preliminary Efficacy Study of CC-99282, Alone and in Combination With Anti-lymphoma Agents in Participants With Relapsed or Refractory Non-Hodgkin Lymphomas (R/R NHL)

Celgene Corporation, a wholly owned subsidiary of Bristol-Myers Squibb Company

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Summary

  • Phase 1/Phase 2
  • Male and Female Gender icon
  • 18+
    Age Range
  • BMS Active Not Yet Recruiting Study icon
    Active, Not Recruiting

Overview

The purpose of this study is to evaluate the safety, tolerability, and preliminary efficacy of CC-99282 alone and in combination with anti-lymphoma agents in participants with relapsed or refractory non-Hodgkin's lymphomas.

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Key Eligibility Criteria

Inclusion Criteria

Inclusion Criteria Icon img
  • History of Non-Hodgkin's Lymphoma (NHL) with relapsed or refractory disease.
    1. Has an Eastern Cooperative Oncology Group (ECOG) performance status of 0, 1 or 2.

      Exclusion Criteria

      Exclusion Criteria Icon
      • Life expectancy ≤ 2 months.
        1. Received prior systemic anti-cancer treatment (approved or investigational) ≤ 5 half-lives or 4 weeks prior to starting CC-99282, whichever is shorter.
          1. Is on chronic systemic immunosuppressive therapy or corticosteroids or has clinically significant graft-versus-host disease (GVHD).
            1. Impaired cardiac function or clinically significant cardiac disease.
              1. Other protocol-defined inclusion/exclusion criteria apply.
                Additional Information *

                Treatment Options

                Study Arms

                ASSIGNED INTERVENTION

                Study Arms

                Experimental: Part A: Dose Escalation

                ASSIGNED INTERVENTION
                • Drug: CC-99282

                Study Arms

                Experimental: Part B: Dose Expansion

                ASSIGNED INTERVENTION
                • Drug: CC-99282, Rituximab, Obinutuzumab, Tafasitamab, Valemetostat

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