Share Icon Health Study Area: Cardiovascular Disease Chevron Icon Health Study Area: Genitourinary For Patients Health Study Area: Lung Cancer Page Icon Phone Icon For Caregivers Health Study Area: AutoImmune Disease Health Study Area: Melanoma Location Icon Print YouTube Icon For Parents Health Study Area: Lung Cancer Print Created with Sketch. Help Icon Green Check Icon Search Icon Instagram Created with sketchtool. Direction Arrow Icon Error Icon For Parents Health Study Area: Blood Cancer Help Icon Health Study Area: NASH Gender Both Bookmark Icon Health Study Area: Melanoma Created with Sketch. Glossary Print Health Study Area: Blood Cancer Health Study Area: Genitourinary Health Study Area: Gastrointestinal Cancer Mobile Menu Icon Created with Sketch. Health Study Area: Cardiovascular Disease Health Study Area: Women's Cancer Communities Map Icon Created with Sketch. For Caregivers Health Study Area: Fibrosis Health Study Area: AutoImmune Disease FAQs Health Study Area: Head and Neck Cancer Created with Sketch. For Clinicians Chevron Right Icon Gender Female Health Study Area: Breast Cancer Direction Arrow Icon Gender Both Right Arrow Icon LinkedIn Icon Green Check Icon Gender Male Health Study Area: Fibrosis For Patients Twitter Icon Email Icon Facebook Icon Health Study Area: Gastrointestinal Cancer Health Study Area: Head and Neck Cancer For Clinicians External Link Icon

Menu

Search BMS Clinical Trials
BMS Active Not Yet Recruiting Study icon

Active, Not Recruiting

Trial ID CA224-073  |   NCT04567615

A Study of Relatlimab in Combination With Nivolumab in Participants With Advanced Liver Cancer Who Have Never Been Treated With Immuno-oncology Therapy After Prior Treatment With Tyrosine Kinase Inhibitors

Warning icon
Sorry, this study is no longer accepting new participants, but is still ongoing.
You may click the “Check Your Eligibility” button and answer a few questions about your health to find out if you might be a match to another study.
Check Your Eligibility

Summary

  • Phase 2
  • Male and Female Gender icon
  • 18+
    Age Range
  • BMS Active Not Yet Recruiting Study icon
    Active, Not Recruiting

Overview

The purpose of this study is to evaluate the effectiveness and safety of relatlimab in combination with nivolumab in participants with advanced liver cancer who have never been treated with immuno-oncology therapy, after prior treatment with tyrosine kinase inhibitor therapy.

print Print
email Email

Key Eligibility Criteria

Key

Inclusion Criteria

Inclusion Criteria Icon img
:
  • Must have a diagnosis of hepatocellular carcinoma (HCC) based on histological confirmation
    1. Must have advanced/metastatic HCC
      1. Have to be immunotherapy treatment-naive in the advanced/metastatic setting
        1. Must have at least one Response Evaluation Criteria in Solid Tumors (RECIST) v1.1 measurable untreated lesion
          1. Child-Pugh score of 5 or 6
            1. Eastern Cooperative Oncology Group (ECOG) performance status 0 or 1 for ECOG performance status scale Key

              Exclusion Criteria

              Exclusion Criteria Icon
              :
              • Known fibrolamellar HCC, sarcomatoid HCC, combined hepatocellular cholangiocarcinoma
                1. Prior organ allograft or allogeneic bone marrow transplantation
                  1. No uncontrolled or significant cardiovascular disease
                    1. No active known autoimmune disease
                      1. Have received one or two lines of tyrosine kinase inhibitor therapies
                        1. Evidence of radiographic progression on or after the last line of tyrosine kinase inhibitor therapy Other protocol-defined inclusion/exclusion criteria apply
                          Additional Information *

                          Treatment Options

                          Study Arms

                          ASSIGNED INTERVENTION

                          Study Arms

                          Experimental: Arm A : Nivolumab

                          ASSIGNED INTERVENTION
                          • Biological: Nivolumab

                          Study Arms

                          Experimental: Arm B : Nivolumab + Relatlimab Dose 1

                          ASSIGNED INTERVENTION
                          • Biological: Nivolumab, Relatlimab

                          Study Arms

                          Experimental: Arm C : Nivolumab + Relatlimab Dose 2

                          ASSIGNED INTERVENTION
                          • Biological: Nivolumab, Relatlimab

                          Help us enhance your website experience! Share your feedback with our team at BMS Clinical Trials to improve yours and others’ experience. Thank you