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Trial ID CA231-0000  |   NCT06476808

A Study to Evaluate the Safety, Tolerability, and Efficacy of Escalating Doses of BMS-986463 in Participants With Select Advanced Malignant Tumors.

Summary

  • Phase 1
  • Male and Female Gender icon
  • 18+
    Age Range
  • 13
    Locations
  • BMS Recruiting Study icon
    Recruiting

Overview

The purpose of this study is to evaluate the safety, tolerability, and efficacy of escalating doses of BMS-986463 in participants with select advanced malignant tumors.

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Key Eligibility Criteria

Inclusion Criteria

Inclusion Criteria Icon img
  • Participants must have an Eastern Cooperative Oncology Group Performance Status of 0 or 1.
    1. Participants must have at least 1 lesion accessible for biopsy in addition to the target lesion, from which a fresh pre treatment biopsy must be obtained.
      1. Participants must have an unresectable/metastatic carcinoma.

        Exclusion Criteria

        Exclusion Criteria Icon
        • Participants must not have Leptomeningeal metastases.
          1. Participants must not have concurrent malignancy (present during screening) requiring treatment or history of prior malignancy active within 2 years prior to treatment.
            1. Participants must not have had any prior radiation therapy within 2 weeks prior to start of study treatment.
              Additional Information *
              • Other protocol-defined Inclusion/Exclusion criteria apply.

                Treatment Options

                Study Arms

                ASSIGNED INTERVENTION

                Study Arms

                Experimental: Arm 1: Dose Escalation

                ASSIGNED INTERVENTION
                • Drug: BMS-986463

                Study Arms

                Experimental: Arm 2: Dose Expansion

                ASSIGNED INTERVENTION
                • Drug: BMS-986463
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