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Phase 3
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RELATIVITY-1093 Study Information
Learn more about the RELATIVITY-1093 / CA224-1093 study
Recruiting
RELATIVITY-1093 is a phase 3, randomized, open-label study of Nivolumab + Relatlimab fixed-dosed combination with chemotherapy versus Pembrolizumab with chemotherapy as first-line treatment for participants with non-squamous, stage IV or recurrent non-small cell lung cancer with tumor cell PD-L1 expression ≥ 1%.
Download and print the details of this study to bring to your doctor.
Patients who are 18 years or older.
Diagnosed with non-squamous stage IV or recurrent NSCLC.
Has not received any prior systemic anti-cancer therapy for advanced disease.
Confirmed not to have EGFR, ALK, or ROS-1 mutations.
PD-L1 Expression ≥1% after testing by central laboratory.
ECOG Performance Status of less than or equal to 1 at both screening and randomization.
Life expectancy of at least 3 months.
*There are other requirements for taking part in this clinical trial which the study staff can explain to you. Talk to your doctor or reach out to your nearest study site using the location finder.
Biomarker testing is one way your doctor can gather information about your NSCLC. A biomarker is a molecule that can be found in tissues, blood, or other body fluids. It can signal that something unusual, like a disease or a health condition, might be happening in the body. It can also help doctors decide what type of treatment is right for you.
What biomarkers are important for this study?
To be eligible for RELATIVITY 1093 study, you:
PD-L1 Expression Levels
a.The PD-L1 Expression is a way for doctors to measure how much of a protein called PD-L1 is on the surface of lung cancer cells. This protein helps cancer hide from the immune system. A higher score means more PD-L1 is present, and doctors use this information to decide if certain treatments, like immunotherapy, might work better to help the immune system fight the cancer.
Relatlimab is a medicine that helps your immune system fight cancer more effectively. Usually, cancer cells find ways to hide from your immune system so it doesn’t recognize them as a threat. Relatlimab works by blocking a protein called LAG-3, which acts like a brake on certain types of immune cells called T-cells. When this brake is turned off, your T-cells can wake up and go after the cancer. Relatlimab is often used with another medicine called nivolumab, and together, they help your body better recognize and attack cancer cells.
Step #1 - The Screening Period
Step #2 - The Treatment Period
Step #3 - The Follow-up Period
Talk to your doctor if you’re interested in joining the RELATIVITY-1093 study. It is important for you to understand all your options before deciding what is right for you. Here are some questions you may want to ask your doctor:
Resources are also available for your healthcare team at Rela1093studyHCP.com >
All BMS Non-Small Cell Lung Cancer Trials
BMS-NSCLCTrials.com