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Trial ID CA240-0008  |   NCT06672523

A Study to Evaluate the Mass Balance, Metabolism, Elimination, and Drug Levels of [14C]-BMS-986504 (MRTX1719) in Participants With Advanced Solid Tumors With Homozygous Methylthioadenosine Phosphorylase Deletion

Summary

  • Phase 1
  • Male and Female Gender icon
  • 18+
    Age Range
  • 2
    Locations
  • BMS Recruiting Study icon
    Recruiting

Overview

The purpose of this study is to evaluate the mass balance, metabolism, elimination, and drug levels of [14C]-BMS-986504 (MRTX1719) in participants with advanced solid tumors with homozygous methylthioadenosine phosphorylase deletion.

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Key Eligibility Criteria

Inclusion Criteria

Inclusion Criteria Icon img
  • Participants must have an advanced, unresectable, or metastatic solid tumor malignancy with a deletion of the methylthioadenosine phosphorylase (MTAP) gene.
    1. Participants must have received, be refractory to, be ineligible for, or be intolerant of available standard care for their cancer.

      Exclusion Criteria

      Exclusion Criteria Icon
      • Participants must not have a history of any surgical or medical conditions possibly affecting how the study drug is distributed, broken down (metabolized) and removed (excreted or eliminated) from the body.
        1. Participants must not have participated in a clinical study involving a radiolabeled study drug within 12 months prior to admission to the research center.
          1. Participants must not have a current or recent (within 3 months of study drug administration) gastrointestinal disease.
            Additional Information *
            • Other protocol-defined Inclusion/Exclusion criteria apply.

              Treatment Options

              Study Arms

              ASSIGNED INTERVENTION

              Study Arms

              Experimental: [14C]-BMS-986504 followed by BMS-986504 Monotherapy

              ASSIGNED INTERVENTION
              • Drug: BMS-986504, [14C]-BMS-986504
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