Recruiting

Trial ID IM027-1012 | NCT06746402

A Study to Investigate the Safety, Tolerability, and Pharmacokinetics of BMS-986278 and the Effects of BMS-986278 on Cardiac Repolarization in Healthy Participants

About This Trial
Key Eligibility Criteria
Trial Site Locations

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Summary

Phase 1
18-55

Age Range
2

Locations
Recruiting

Overview

The purpose of this study is to determine the safety, tolerability, and pharmacokinetics (PK) of high dose of BMS-986278 in healthy participants and to assess the effect of BMS-986278 on the ECG intervals in healthy participants.

Nearest Recruiting Site

Key Eligibility Criteria

Inclusion Criteria

:

Female individuals not of childbearing potential (INOCBP) and males.
Healthy as determined by medical history, physical examination, vital signs, 12-lead ECG, and clinical laboratory assessments.
Body mass index (BMI) 18.0 to 32.0 kg/m2 , inclusive, for Parts A and B.

Exclusion Criteria

:

Any significant acute or chronic medical illness as determined by the investigator.
History of clinically relevant cardiac disease as determined by the investigator, symptomatic or asymptomatic arrhythmias, presyncope or syncopal episodes, or additional risk factors for ventricular arrhythmias.
Any significant history of disease of the cardiovascular system that in the opinion of the Investigator makes the participant unsuitable for enrollment into the study.
Other protocol-defined inclusion/exclusion criteria apply.

Additional Information *

Treatment Options

Study Arms

ASSIGNED INTERVENTION

Study Arms

Experimental: Part A

ASSIGNED INTERVENTION

Drug: BMS-986278, Placebo

Study Arms

Experimental: Part B1/B2 Treatment A

ASSIGNED INTERVENTION

Drug: BMS-986278

Study Arms

Experimental: Part B1/B2 Treatment B

ASSIGNED INTERVENTION

Drug: BMS-986278, Placebo

Study Arms

Experimental: Part B1/B2 Treatment C

ASSIGNED INTERVENTION

Drug: Placebo

Study Arms

Experimental: Part B1/B2 Treatment D

ASSIGNED INTERVENTION

Drug: Placebo, Moxifloxacin

Study Arms

Experimental: Part B3 Treatment A

ASSIGNED INTERVENTION

Drug: BMS-986278

Study Arms

Experimental: Part B3 Treatment B

ASSIGNED INTERVENTION

Drug: BMS-986278, Placebo

Study Arms

Experimental: Part B3 Treatment C

ASSIGNED INTERVENTION

Drug: Placebo

Study Arms

Experimental: Part B3 Treatment D

ASSIGNED INTERVENTION

Drug: Placebo, Moxifloxacin

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