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Trial ID CA254-0001  |   NCT07160725

A Phase 1/2a, First-in-human, Study of BMS-986517 in Participants With Advanced Solid Tumors

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Summary

  • Phase 1/Phase 2
  • Male and Female Gender icon
  • 18+
    Age Range
  • 15
    Locations
  • BMS Not Yet Recruiting Study icon
    Not Yet Recruiting

Overview

A phase 1/2a, open-label, first-in-human study mainly aimed to evaluate the safety and tolerability of BMS-986517 in participants with solid tumors

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Key Eligibility Criteria

Inclusion Criteria

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:
  • Participants must have an ECOG performance status of 0 to 1.
    1. Participants must have measurable disease by RECIST v1.1 (radiologically measured by the Investigator).
      1. Participants must have documented histologically or cytologically confirmed advanced, unresectable/metastatic solid tumors, including NSCLC, HNSCC, TNBC, and HR+/HER2
        1. breast cancer.

          Exclusion Criteria

          Exclusion Criteria Icon
          :
          • Participants must not have untreated CNS metastases. Participants are eligible if CNS metastases have been treated and do not require immediate treatment or have been treated and have neurologically returned to baseline (except for residual signs or symptoms related to the CNS treatment).
            1. Participants must not have concurrent malignancy (present during Screening) requiring treatment or history of prior malignancy active within 2 years prior to treatment assignment.
              1. Participants must not have history of serious recurrent infections.
                1. Participants must not have impaired cardiac function or history of severe heart disease.
                  1. Other protocol-defined inclusion/exclusion criteria apply.
                    Additional Information *

                    Treatment Options

                    Study Arms

                    ASSIGNED INTERVENTION

                    Study Arms

                    Experimental: Part 1

                    ASSIGNED INTERVENTION
                    • Drug: BMS-986517

                    Study Arms

                    Experimental: Part 2: Cohort A

                    ASSIGNED INTERVENTION
                    • Drug: BMS-986517

                    Study Arms

                    Experimental: Part 2: Cohort B

                    ASSIGNED INTERVENTION
                    • Drug: BMS-986517

                    Study Arms

                    Experimental: Part 2: Cohort C

                    ASSIGNED INTERVENTION
                    • Drug: BMS-986517
                    Please check back later for a recruiting site or find another trial by clicking 'Check Your Eligibility'
                    Check Your Eligibility
                    Answer some questions about Your health to see if you may match to this trial
                    Match to a Trial
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