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Trial ID IM062-0001  |   NCT07412704

A Study of BMS-986528 in Participants With Refractory Rheumatoid Arthritis

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Summary

  • Phase 1/Phase 2
  • Male and Female Gender icon
  • 18-65
    Age Range
  • 17
    Locations
  • BMS Not Yet Recruiting Study icon
    Not Yet Recruiting

Overview

The purpose of this study is to evaluate the safety, tolerability, pharmacokinetics (PK), pharmacodynamics (PD), and the preliminary evidence of disease-modifying effect of BMS-986528 in participants with refractory, difficult-to-treat rheumatoid arthritis (RA).

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Key Eligibility Criteria

Inclusion Criteria

Inclusion Criteria Icon img
  • Adult participants with rheumatoid arthritis (RA) who meet definition of difficult-to-treat.

    Exclusion Criteria

    Exclusion Criteria Icon
    • Juvenile arthritis or onset of inflammatory arthritis before age 18.
      1. Seronegative RA participants in whom polymyalgia rheumatica has not been ruled out.
        1. Active fibromyalgia with pain symptoms or signs that would interfere with joint assessment.
          Additional Information *
          • Other protocol-defined Inclusion/Exclusion criteria apply.

            Treatment Options

            Study Arms

            ASSIGNED INTERVENTION

            Study Arms

            Experimental: Cohort A1

            ASSIGNED INTERVENTION
            • Drug: BMS-986528

            Study Arms

            Experimental: Cohort A2

            ASSIGNED INTERVENTION
            • Drug: BMS-986528

            Study Arms

            Experimental: Cohort A3

            ASSIGNED INTERVENTION
            • Drug: BMS-986528

            Study Arms

            Experimental: Cohort A4

            ASSIGNED INTERVENTION
            • Drug: BMS-986528

            Study Arms

            Experimental: Cohort A5

            ASSIGNED INTERVENTION
            • Drug: BMS-986528

            Study Arms

            Experimental: Cohort A6

            ASSIGNED INTERVENTION
            • Drug: BMS-986528

            Study Arms

            Experimental: Cohort A7

            ASSIGNED INTERVENTION
            • Drug: BMS-986528

            Study Arms

            Experimental: Cohort A8

            ASSIGNED INTERVENTION
            • Drug: BMS-986528

            Study Arms

            Experimental: Cohort B1

            ASSIGNED INTERVENTION
            • Drug: BMS-986528

            Study Arms

            Experimental: Cohort B2

            ASSIGNED INTERVENTION
            • Drug: BMS-986528
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